Specialty Bead Properties

BioScience beads with microcrystalline starch in 4% agarose bead; mag: 100 X

BioScience beads with microcrystalline starch in 4% agarose bead; mag. 400X

BioScience enzymatically sulfated gel bead stained with toluidine blue; 180-350µ; mag 100X

Unique BioAffinity Options:

Often, the incorporation of micon-sized particles in the agarose gel will impart special properties which cannot be achieved - cost effectively- through chemical derivatization. In addition, certain stereochemistries inherent in natural products are almost impossible to reproduce through chemical derivatization of the agarose gel. For these reasons, we encourage the use of micron-sized gel inclusions and/or special, functionalized polymers within the agarose gel as a means of achieving the desired functional properties for a specialty bead.

The schematic diagram, below, illustrates how small particles can be randomly distributed throughout the gel. Because of the high porosity of the agarose gel, solutes and target substances can diffuse into the gel and interact with the functional surface of the microparticles.

Often, more than one type of particle will need to be dispersed in order to achieve the right balance of properties : for example, magnetism and hydrophobicity. Also shown in the diagram, is how one or more specially functionalized polymers can be dispersed and immobilized within the agarose gel so as to provide a unique functionality : for example, a heparin-like affinity. Gels containing functionalized polymers can also contain one or more particles to obtain the desired overall functionality:for example, magnetic susceptability and heparin-like properties.

Specialty Bead Selection Guide

Note: Unlike other sections, the agarose concentration can be varied over the range from 1-10%; Average bead size and bead size interval may also be varied over the range from 10-500μ ; Special derivatives and derivative combinations are also options.

Reference Brand Name BioScience Bead Equivalent (code) Settled Bead Volume Catalog Number BioScience Bead Price Target Application(s)
Re: Gel Filtration (SEC) Beads
Various Options noted above Various to be assigned Inquire Various
Re: Ion Exchange Beads
Various Options noted above Various to be assigned Inquire Various
Re: Affinity Beads
Various Options noted above Various to be assigned Inquire Various
Re: Cell Separation Beads
Various Options noted above Various to be assigned Inquire Various
Re: Hydrophobic Beads
Various Options noted above Various to be assigned Inquire Various
Re: Magnetic Beads
Various Options noted above Various to be assigned Inquire Various
Other Specialty Beads
No commercial counterpart Agarose-entrapped, activated charcoal Beads 10 ml AC-A-0400-0100 $8.00 Removal of dye and other low MW organics
100 ml AC-A-0400-0010 $50.00
>100 ml to be assigned Inquire
No commercial counterpart Magnetic, Agarose-entrapped, activated charcoal Beads 10 ml MAC-A-0400-0100 $10.00 Magnetic removal of dye and other low MW organics
100 ml MAC-A-0400-0010 $80.00
No commercial counterpart Agarose-entrapped microglass Beads Various to be assigned Inquire Various
No commercial counterpart Other Agarose-entrapped microparticle Beads Various to be assigned Inquire Various

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